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Drawing the link between immunity and oxidative stress

A series of seminars dedicated to immunity and oxidative stress in variuos animal species (swine, poultry, ruminant, equine) took place in France,  November 14-15 with two sessions in Rennes (Britany) and Toulouse (South-West), gathering altogether more than 50 players from the feed industry. Moving from basic science to field applications, this meeting was a great illustration of Lallemand Animal Nutrition “field-led science-supported” product development strategy.

The meeting started by in-depth lecture from Florence Barbé, researcher at Lallemand, about the causes and mechanisms of oxidative stress and its consequences at farm level. This brought participants a better understanding of the different types of antioxidant strategies for animal nutrition, in particular the difference and complementarity of primary and secondary antioxidants. As Julien Delforge, moderator of the meeting concluded: “when considering antioxidant formulation, it is more effective to use a combination of different, complementary types of antioxidants rather than saturating one antioxidant pathway with a single solution”.

Field-led science-supported solutions

Moving on to applied science, the meeting was then the occasion to highlight how advanced technologies and analysis methods brought a better understanding of the  effects and  modes of action of some nutritional solutions for oxidative stress and immune defenses:

  • Organic selenium source ALKOSEL: benchmark analysis demonstrated that not all selenium yeast are equivalent, giving some keys to select the best source of organic selenium.
  • Primary antioxidant source MELOFEED: Audrey Sacy delivered the latest pieces of the puzzle of the modes of action of this natural source of super oxide dismutase, its effects on animal oxidative status and immunity, as well as some technical data about its formulation (resistance to feed pelletization and digestion…).
  • The last born from Lallemand‘s R&D: new generation yeast derivative YANG. Bruno Bertaud, Product Manager, showed how hardcore scientific tool (atomic force microscopy) was used to screen and select yeast strains for optimal pathogen-binding and immune modulation activity.

From science to farm practice

The last part of the seminar reviewed some of the major challenges at farm level and showed the effects of adequate antioxidant and immune support strategies at critical stages of the animals’ life cycle:

  • Reproduction: trials indicate benefits on fertility, reproductive performances, with consequences on the newborn maturity and vitality, with illustrative data in poultry and swine.
  • Weaning: data in pre-ruminant and piglet indicate a better resistance to the stress of weaning, preserving the animal performance and welfare. YANG is particularly documented in calf; lamb, goat and piglet.
  • Immune response challenges: immune modulation through an enhanced oxidative status. For example, increased resistance to inflammatory challenge in piglets, reduced somatic cell count in milk in ruminants etc.
  • Intense exercise: antioxidant protects muscle and joint damage during intense training in horses.

Since immunity and oxidative stress involve cellular mechanisms that are common to most animal species, this meeting was a great opportunity to share experiences between various species, and show that Lallemand’s antioxidant and yeast derivatives solutions show robust effects across all species.