ZooParc de Beauval Launched Trial to Improve Penguin Immunity Against Aspergillosis with microXpace and Lallemand Animal Nutrition

ESSONE, FRANCE – March 10, 2025 – ZooParc de Beauval, one of France’s most renowned zoological parks, has launched an innovative trial to assess immune stimulation in penguins, in collaboration with microXpace, the company behind “The Right Sugar,” and Lallemand Animal Nutrition, a global leader in microbial solutions for companion animals and livestock. The study explores how a postbiotic-associated immune stimulation strategy may help enhance penguins’ immunity against aspergillosis, a respiratory disease that poses a significant risk to birds in zoological settings. 

A Preventive Approach to Aspergillosis in Penguins 

Aspergillosis, caused by the fungal pathogen Aspergillus fumigatus, is a major health challenge for birds in zoo environments, particularly penguins. This trial examines whether modulating alpha-Gal immunity through a postbiotic-based approach can help enhance the birds’ natural immune response against this pathogen. Alpha-Gal, a microbial sugar naturally present in certain gut bacteria, stimulates the production of natural anti-alpha-Gal antibodies. By leveraging this mechanism, the study explores how microbial-driven stimulation can strengthen the birds’ defences against aspergillosis. To ensure targeted delivery, alpha-Gal glycans are encapsulated and administered via fish, aiming to optimize the penguins’ natural antibody response against Aspergillosis. 

“Aspergillosis is a severe disease that is both complicated to diagnose and to treat in birds, and more specifically in penguins, resulting in high mortality rates. Therefore, prevention of the disease is of paramount importance,” said Dr. Antoine Leclerc, DVM, Dipl. ECZM (ZHM), head veterinarian at ZooParc de Beauval. “Given the high prevalence and mortality rates associated with aspergillosis in penguins, development of a vaccine, or any means to stimulate penguin immune response to prevent the disease is definitely one of the key challenges in zoological medicine nowadays. We hope that the findings of this trial will be a significant milestone, and will benefit to all zoological institutions hosting penguins.” 

Scientific Innovation in Avian Immune Modulation

ChickGalX’s formulation is based on a precisely selected glycan structure, including alpha-Gal, a microbial sugar known for its role in naturally stimulating antibody responses in birds. By leveraging this mechanism, the study explores how targeted glycan exposure may enhance the immune system’s ability to defend against aspergillosis.

“Our goal is to harness nature’s most effective biological mechanisms to support animal well-being,” said Dr. Dasiel Obregón Alvarez, co-founder and head of the avian division at microXpace. “By introducing alpha-Gal—‘The Right Sugar’—we are leveraging a natural microbial molecule that helps stimulate the immune system, giving zoos like ZooParc de Beauval an innovative tool to enhance penguin resilience against Aspergillosis.” 

The trial will be closely monitored over the coming months, with ZooParc de Beauval’s veterinary and research teams tracking immune markers and health outcomes. 

“This initiative will allow us to combine our expertise in microbial solutions with the practical animal care knowledge to establish new best practices for penguin nutrition in zoological settings,” said Mathieu Castex, general manager and president at Lallemand Animal Nutrition. “We are excited to contribute our expertise to the development of ChickGalX. This collaboration with ZooParc de Beauval and microXpace exemplifies our commitment to advancing microbial based solutions to support the welfare of animals in our care.” 

Unlike traditional preventive measures, ChickGalX leverages cutting-edge research in microbial immunity to explore novel strategies for enhancing penguin disease resistance in zoological settings. The initiative is grounded in scientific research exploring microbial glycans’ role in supporting natural immune defenses in zoological species. 

The trial will unfold over the coming months, with key findings and insights shared via ZooParc de Beauval’s official website and the social media channels of microXpace and Lallemand Animal Nutrition. Penguin lovers, conservationists, and wildlife enthusiasts are encouraged to follow along as we explore how The Right Sugar fits into the broader landscape of penguin health and welfare. 

Contact

Lallemand Animal Nutrition 
Kim Limberg 
M: (+33) 6 78 81 04 82 
E: klimberg@lallemand.com 

About ZooParc de Beauval

Zoo Parc de Beauval is a vibrant destination for families and wildlife enthusiasts alike. Dedicated to conservation, education, and exceptional visitor experiences, the park features a diverse range of animal species showcased in naturalistic settings. Through innovative and interactive programs, Zoo Parc de Beauval inspires a deeper understanding of biodiversity and the importance of environmental stewardship. With a strong commitment to animal welfare and sustainable practices, the park continues to serve as both a sanctuary for wildlife and a catalyst for conservation efforts for generations to come. For more information, please visit www.zoobeauval.com/ 

About microXpace

microXpace is a DeepTech company recognized by Bpifrance, specializing in advanced microbial fermentation technologies to deliver precision-formulated feed materials for aquaculture, poultry, companion animals, and beyond. Our work bridges scientific innovation with practical nutrition to develop products that enhance feed quality and nutrient availability without relying on medical or therapeutic claims. We leverage our patented glycan technologies to create feed materials that support sustainable food production and animal well-being, aligning with the One Health initiative. Our commitment extends to fostering collaborations with academic institutions, biotech pioneers, and industry leaders to continuously push the boundaries of microbial-based nutritional solutions. For more information, please visit www.microxpace.com 

About Lallemand Animal Nutrition

We are Lallemand Animal Nutrition – a global leader in the science of fermentation – and a primary producer of yeast and bacteria. Our passion is harnessing microorganisms to improve performance and maintain animal health, optimize forage management, and the animal microbial environment. We remain unwavering in our commitment to helping our industry partners and farmers sustainably feed a growing global population through improved animal performance – and supporting the health and well-being of aquaculture, livestock and companion animals.  

We provide a very broad range of innovative microbial products, services and solutions for customers around the world. We deliver tailor-made services according to your specific needs and offer expert technical support to ensure the optimal application and efficacy of our solutions. 

Leveraging the natural power of yeast and bacteria, we develop, produce and market highly technical products including probiotics, silage inoculants, and microbial derivatives. Using sound science, proven results and knowledge from experience, we apply the right strains for the right applications. For more information, please visit www.lallemandanimalnutrition.com